Andropause and Men
What I witnessed in 1978 at Johns Hopkins working with W.W. Scott on the NCPC project has had a lasting impression on my practice. We cared for 100 men with advanced prostate cancer who went into rapid "Andropause" with surgical or chemical castration. They all abruptly had "hot flashes", lost bone, lost muscle in exchange for a fat belly, lost blood with fatigue, lost erections, many became diabetics with abnormal glucose tolerance tests, but most of all, lost interest in life.

In a one year period I saw a "fast movie forward" of what happens to aging men over a 30 year period. From age 40, there is a 2% decline in testosterone each year and therefore it is a "slow motion" of what I witnessed. Testosterone response is "Adaptive" depending on you- if you have sleep apnea, your testosterone goes down. If you sit at the computer all day, testosterone goes down- you can lessen the decline!

In the past we just accepted that the testosterone- dominated sex hormone balance in youth was bad as you got "older". But today, as longevity increases, we know how important the "Anabolic" component (muscles, bone, blood and more recently, the "smooth" involuntary muscles of the penis and heart muscles and insulin sensitivity) depend on testosterone. Without testosterone there is Insulin Resistance. The "Androgenic" component effecting prostate enlargement (urine blockage) and prostate cancer occurs, not in youth, but from late 60s on, are the result of shifting imbalances between testosterone to estradiol estrogen.

The surge to use Avodart as a preventive measure as well as in conjunction with chemical castration for advanced prostate cancers is based on the Androgenic component of testosterone and the prostate gland. In the future estrogen blockage will have a place in the management of the prostate gland.

We believe in the importance of balancing the Anabolic and the Androgenic effects on the whole body as well as the prostate gland and tailor a program for each man according to his social, nutritional, and medical history.